About ACTs

ACT = (Artemisinin Combination Therapy)

What does the WHO, FDA and the CDC say about ACTs?

The U.S. Federal Drug Administration (FDA) and the Center for Disease Control (CDC) are both U.S. agencies that have minor experience in the modern era of Malaria treatment because Malaria is virtually non-existent in the North American hemisphere in the last 100 years. That having been said, artemisinin treatments are acknowledged as proven treatments for the disease.

The World Health Organization (WHO) has been actively promoting the use of ACTs as the only proper treatment for Malaria since 2003.  Despite their efforts the widespread misuse of SP (sulfadoxine/pyrimethamine) and chloroquine (which in the past has been cheaper to produce) have been used pervasively for decades. Much of the problem stems from the distribution of ACT formulas to the areas where it’s needed. ActRx has found a way to produce the formula in sufficient quantities of scale that allow us to offer it at a price that is competitive with choloroquine.

The ActRx ACT Combination Formula

The ActRx ACT combination formula is the first to combine Artesunate with Berberine (Patent Pending) which provides an effective treatment for many serious ailments that both local residents as well as travelers encounter in certain global regions, such as the Malaria parasite and potentially many others such as Dysentery (diarrhea), or the Dengue Fever virus.

From the WHO (2010)

Plasmodium falciparum Malaria, a life-threatening disease, occurs in the tropics and subtropics, in >90 countries, and caused an estimated 863,000 deaths in 2008.

P. falciparum is the predominant Malaria parasite in endemic areas of tropical Africa. During the transmission season in endemic areas, all non-immune travellers who are exposed to mosquito bites between dusk and dawn are at risk of Malaria. Travellers' risk of contracting Malaria varies from country to country and among areas in a country.

Prevention and treatment of falciparum Malaria with antiMalarial medicines have become more difficult because the parasite is increasingly resistant to various antiMalarial drugs. Artemisinin and artemisinin-derivatives are medicines used to treat falciparum Malaria strains that have become resistant to many different drugs; they are the core component of the widely used WHO-recommended artemisinin-based combination therapies (ACT– combinations of artemisinin, or one of its derivatives, with one or more antiMalarials of a different class). WHO now recommends the use of ACT as standard first-line treatment for uncomplicated Malaria.

Doctors Prescribing Chloroquine

If the WHO recommends ACTs exclusively, why are doctors still prescribing chloroquine for those infected with Malaria?

In a word "access." It's only the preferred treatment when it's the only treatment. The side effects of chloroquine and the resistance of the Malaria parasite are well documented but ACTs are not in wide enough supply.

The factors combined make chloroquine both ineffective and damaging. ACT formulas are not only preferred but officially mandated by the World Health Organization (WHO) as the only correct solution for the treatment of Malaria. A failure to follow the mandate could result in increased deaths and further growth of the disease.

What about choloroquine and SP?

Both choloroquine and SP (sulfodoxine pyramethamine) now failed as a treatments for Malaria, in addition to the mind-altering side effects. At one point they did work as a cure, but in the majority of malarious countries the parasite has become immune to these treatments and they cause more harm then they solve.

What is the ActRx Treatment

The ActRx Treatment is a must have for anyone living in or traveling within an area where dangerous infectious diseases are known to exist. Those not familiar with more exotic locales should be aware that modern medical treatment is not always readily available in outlying areas, and even when it is, they may not be familiar with the latest effective treatments for Malaria. Malaria is a potentially lethal condition that can quickly be remedied with the ActRx Treatment.

The ActRx ACT combination formula is designed as a highly effective, easy to administer treatment, if you contract Malaria and become sick. The first dose of the full four day dosage will typically show results within the first four hours with considerable restorative results in a variety of cases in the first 24 hours.

Natural Compounds

ActRx is composed of naturally derived substances, with minimal to no side effects.

Malaria is still a major global pandemic. What do you project as the size of the market for the ACT formula?

The size of the Malaria problem is difficult to assess with many of the worst areas in sub-Suharan Africa where accountable documentation is minimal. The 863,000 documented deaths reported by the WHO grossly underestimate the size of the problem. Most popular estimates put the number infected at 400-500 million in the world today. This includes many individuals that carry the disease even if they don’t exhibit the symptoms. Malaria is a blood-borne pathogen. Patients treated with chloroquine in the past may experience positive results for their symptoms, but the parasite lives on in their liver and blood. Only the ACT formula actually kills the actual parasite for good preventing its spread.   ActRx has the potential to save millions of lives worldwide.

Recent deaths reported in the news have been linked to contaminated heperine sourced from labs in China. What are you as a patient doing to ensure the quality of the ACT products you may choose to use for treatment?

GMP - "Good manufacturing practice" are practices and the systems required to be adapted in pharmaceutical manufacturing, quality control, quality system covering the manufacture and testing of pharmaceuticals or drugs including active pharmaceutical ingredients, diagnostics, foods, pharmaceutical products, and medical devices. GMPs are guidance that outline the aspects of production and testing that can impact the quality of a product...(Wikipedia, the free encyclopedia).   ActRx is manufactured following the GMP standards and guidelines.

Why aren’t more major pharmaceutical companies competing to deliver ACTs to the market?

Many of the top global pharma groups have small projects marketed under OEM trade names, but typically "big pharma" companies are focused more on high profit business from synthetic proprietary drugs with significant return ratios that justify their tremendous R & D budgets. The ActRx ACT formula uses naturally derived substances, and is offered for sale at minimal cost to the end user or distributing organization. While ActRx does carry a nominal profit to cover the staff, manufacturing and distribution costs, we do our best to serve a humanitarian objective as part of our corporate culture. Our drive is to make the ActRx Treatment affordable and highly available, as compared to other similar or viable treatments.   The ActRx company motto, "To Save a Life...", deeply reflects the focus of the Company... To provide a safe and effective treatment for the global elimination of Malaria and other deadly infectious diseases.

If ACTs are the best solution for Malaria, why haven’t I heard about it before?

Many of the early ACTs went as giant container loads shipped directly to Africa and South America, where the problem was most severe. Those ACTs were not made commonly available to travelers or local residents.   The ActRx Malaria Treatment offered by ActRx Limited now makes it possible to obtain this product in many regions around the world, through governments, NGOs and various other organizations.

Is the ActRx combination formula patented or is it generic?

We are the first to combine these two unique, natural and proven ingredients into one powerful ACT formula for the treatment of Malaria.   The ActRx combination formula is Patent Pending.

Severe Malaria in Children - WHO Guidelines

It is essential that effective, parenteral (or rectal) anti-Malarial treatment in full doses is given promptly in severe Malaria. Two classes of medicines are available for the parenteral treatment of severe Malaria: the cinchona alkaloids (quinine and quinidine) and the artemisinin derivatives (artesunate, artemether and artemotil).   NOTE: Parenteral chloroquine or  Intramuscular sulfadoxine-pyrimethamine is no longer recommended by the WHO for the treatment of severe Malaria because of widespread resistance.   The ActRx Treatment combines Artesunate and/or Artemether and Berberine as a highly effective ACT treatment to defeat the Malaria infection.